Governance
ASCOT International Trial Steering Committee (ITSC)
The ITSC includes clinical trialist, biostatisticians, regional lead investigators, domain led investigators and project managers
| Asha Bowen (Chair) | Joshua Davis | Naomi Hammond |
| Bala Venkatesh | Justin Denholm | Steven Tong |
| David Paterson | Matthew O'Sullivan | Susan Morpeth |
| David Price | Megan Rees | Tom Snelling |
| Jason Roberts | Nanette Trask | Vivekanand Jha |
| Zoe McQuilten | Bhupendra Basnet |
ASCOT Sponsorship Committee
The board is responsible for monitoring quality control of the data, progress of recruitment and safety aspects of the trial.
| Mark Rosenthal (Chair) | Sarah Rickard | Sharon Lewin |
| Andrea Fischer | Mark Hargreaves | Steven Tong |
| David Paterson | Mark Sullivan |
Data and Safety Monitoring Board (DSMB)
The board is responsible for monitoring quality control of the data, progress of recruitment and safety aspects of the trial.
| Anthony Kelleher (Chair) | Anne Chang | David Price |
| Lorenza Trippa | Ralph Stewart | Prakash Ghimire |
| Thomas Jaki | James Totterdell |
Statistical Committee
The Statistical Committee is responsible for the development of the statistical analysis plan and provides recommendations for the analysis of the outcome data.
| Tom Snelling (Co-Chair) | Justin Denholm | Ian Marschner |
| David Price (Co-Chair) | Julie Marsh | James McGree |
| Steven Tong | Mark Jones | Gian Luca Di Tanna |
| Joshua Davis | Tim Spelman |
Biobanking Steering Committee (ABC)
The ABC oversees sample collection, storage and applications for sample access related to biological research undertaken in ASCOT.
| Justin Denholm (Chair) | Priyanka Pillai | Paula Ellenberg |
| David Paterson | Vi Nguyen | Mahesh Moorthy |
| Gagandeep (Cherry) Kang | James McFadyen | Susan Morpeth |
| Edward Raby | Jason Roberts | Katie Flanagan |
| Craig Gedye | Damian Purcell | Judy Chang |
| Michael Maze |
Pregnancy Working Group
The pregnancy working group oversees the development of pregnancy specific eligibility criteria and data collection for the ASCOT ADAPT protocol.
| Megan Rees (Co-Chair) | Asha Bowen | Sourabh Dutta |
| Clare Whitehead (Co-Chair) | Adrienne Gordon | |
| Susan Walker | Michelle Giles |
Domain-Specific Working Group (Antiviral, Antibody, Anticoagulation)
There will be a DSWG for each active and future planned domain. The DSWGs will be responsible for monitoring the current and potential interventions within a domain.
Antiviral
| Susan Morpeth (Co-Chair) | Tom Hills | Megan Rees |
| Bala Venkatesh (Co-Chair) | David Paterson | Sharon Lewin |
| Steven Tong | Jason Roberts | Gagandeep (Cherry) Kang |
| Joshua Davis | Greg Dore |
Antibody
| Zoe McQuilten (Co-chair) | Erica Wood | Susan Morpeth |
| Matthew O'Sullivan (Co-chair) | James Daly | Veronica Hoad |
| Steven Tong | Iain Gosbell | Tom Hills |
| Richard Charlewood | Aikaj Jindal | Kristina Kairaitis |
Anticoagulation
| Zoe McQuilten (Co-chair) | Sanjeev Chunilal | Eileen Merriman |
| Jason Roberts (Co-chair) | James McFadyen | Jennifer Curnow |
| Huyen Tran | Robert Medcalf | Joseph John |
Region-Specific Working Groups
The RSWGs are responsible for identification and management of sites and study documents within that region.
ANZ
| Justin Denholm (Co-chair) | Jane Davies | Nigel Raymond |
| Susan Morpeth (Co-chair) | Naomi Knoblauch | Eamon Duffy |
| Michael Maze | Jack Dummer | Lou Irving |
| Emily Rowe | Peter Wark | Andrew Burke |
| Alison Ratcliff | Sandra Hodge | James Molton |
India and Nepal
| Gagandeep Kang (Co-Chair) | Naomi Hammond | Oommen John |
| Vivek Jha (Co-Chair) | Bala Venkatesh | Mahesh Moorthy |
| Dipak Haksar | Steven Tong | Zoe McQuilten |
| Aikaj Jindal | Susan Morpeth | Joseph John |
| Abhinav Bassi | Baldeep Kaur | Suman Pant |
| Santa Kumar Das | Ashesh Dhungana | Purnima Rao Jevaji |
Sub-Study Committees
The sub study committees will review any proposals for additional studies to the main protocol, designed to ask a separate research question and initiate new data collection from the trial participants.
The Analytic Team
The analytic team is responsible for the conduct of the planned interim analyses by running the predetermined statistical models and providing the output to the DSMB.
Regional hubs
NT, SA, TAS, VIC, WA: The Peter Doherty Institute for Infection and Immunity (The Doherty)
ACT, NSW: Hunter Medical Research Institute (HMRI)
QLD: University of Queensland Centre for Clinical Research (UQCCR)
India and Nepal: The George Institute (TGI)
New Zealand: Middlemore Clinical Trials (MMCT)
Denmark: Centre of Research & Disruption of Infectious Diseases (CREDID)